Human trypanolytic factor apol1 forms

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August undefined, 2024

WebThe Trypanosoma brucei subspecies T. brucei brucei is non-human infective due to susceptibility to lysis by trypanolytic factor (TLF) in human serum. Reviewed here are … WebHuman trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. Proc. Natl. Acad. Sci. U.S.A. 2015; 112: 2894-2899. Crossref; PubMed; Scopus …

OPINION The trypanolytic factor of human serum

Web17 feb. 2015 · APOL1 is a cation channel forming protein that inserts into lipid bilayers at acidic pH and forms a closed-state ion channel. These channels are gated by pH, such … Web7 mei 2014 · APOL1 is the main trypanolytic component of human trypanosome lytic factor (TLF). TLF consists of two HDL subfractions (TLF1 and TLF2) that contain … nistler farm corgis

(Open Access) Antioxidant and Anti-Inflammatory Role of …

Web18 jan. 2024 · Thomson R, Finkelstein A. Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. … WebConsistent with previous work, 1,2 we found elevated frequencies of the APOL1 haplotype in African-American, sub-Saharan African, and Western African populations (11 to 32%). … Web28 dec. 2006 · This serum was remarkably devoid of APOL1, a protein identified as a trypanolytic factor of normal human serum in the case of T. brucei brucei. 4-6 The lack … nista orthodontics

The trypanolytic factor of human serum - Nature

A human apolipoprotein L with detergent-like activity kills

Web5 okt. 2015 · We discuss two models for APOL1 trypanolytic activity: one involving lysosome permeabilization and another involving colloid-osmotic swelling of the cell … Web9 jul. 2024 · APOL1 is a cation channel forming protein that inserts into lipid bilayers at acidic pH and forms a closed-state ion channel. These channels are gated by pH, such … nist time broadcastWeb1 nov. 2024 · Until the APOL1 renal risk variants were identified in 2010, there had been no suspicion that APOL1 was important in the kidney in either health or disease. 1, 2 … nist traceable co2 meter

"Web17 feb. 2015 · Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei gambiense, which are … " - Human trypanolytic factor apol1 forms

Human trypanolytic factor apol1 forms

(Open Access) Antioxidant and Anti-Inflammatory Role of …

Web14 apr. 2024 · Africa, particularly sub-Sharan Africa (SSA), faces major challenges in respect to chronic kidney disease (CKD). There is a rising prevalence due to the … Web19 dec. 2024 · ApoL1, the protein product of APOL1, is mostly secreted into the serum by the liver and is found in high-density lipoprotein or complexed to IgM; it is also expressed …

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Web9 aug. 2024 · Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. Proc Natl Acad Sci U S … Web1 feb. 2024 · APOL2, the closest APOL1 homolog, is not trypanolytic [6] despite the presence of both the transmembrane hairpin helix and transmembrane HC2 containing …

WebCultures of SE1 (Staby®) strains transfected with pStaby1.2 (Delphi Genetics) harboring the different APOL constructs were grown at 37°C in LB containing 1% glucose and 50 μg … WebApolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human …

Web14 apr. 2024 · The APOL1 gene encodes for the protein apolipoprotein L1. Historically, this gene grants innate immunity against most strains of Trypanosoma brucei. Two gain-of-function Apolipoprotein L1 (APOL1) variants G1 or G2 were first determined among individuals of African descent with a high prevalence found in Western Africa [ 8, 9 ]. Web14 apr. 2024 · Much of this disparity can now be attributed to genetic variants in the apoL1 (apoL1) gene, a gene found only in individuals of recent African ancestry. These variants greatly increase the incidence of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of non-diabetic nephropathy.

Web14 aug. 2024 · Thomson R, Finkelstein A. Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. …

Web7 mei 2014 · Human-infective T. b. rhodesiense, which causes acute African sleeping sickness, arose from animal-infective T. b. brucei through the evolution of a virulence … nist000198 stor fas2750WebAPOL1 transits to the trypanosomal lysosome and inserts in the membrane, causing lysosomal swelling and leading to the death of the trypanosome. (B) The normal function … nist windows firewallWeb29 mrt. 2024 · Human blood contains trypanolytic factors, composed of haptoglobin-related protein, apolipoprotein L1 (APOL1), apolipoprotein A1 (APOA-1), and IgM. … nist what isWebHuman trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers : Relevance to trypanosome lysis. / Thomson, Russell; Finkelstein, Alan. In: … nist viscosity properties gasWeb14 apr. 2024 · Much of this disparity can now be attributed to genetic variants in the apoL1 (apoL1) gene, a gene found only in individuals of recent African ancestry. These variants … nistawoyou friendship centreWeb12 jun. 2024 · The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the … nistitl type 7 record fields nist what is ai